SINGLE-CELL PROFILING SHOWS MURINE FOREBRAIN NEURAL STEM CELLS REACQUIRE A DEVELOPMENTAL STATE WHEN ACTIVATED FOR ADULT NEUROGENESIS

Single-Cell Profiling Shows Murine Forebrain Neural Stem Cells Reacquire a Developmental State when Activated for Adult Neurogenesis

Summary: The transitions from developing to adult quiescent and activated neural stem cells (NSCs) are not well understood.Here, we use single-cell transcriptional profiling and lineage tracing to characterize these transitions in the murine forebrain.We show that the two forebrain NSC parental populations, embryonic cortex and ganglionic Climbing

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